Among adults with Hashimoto's thyroiditis who have normal selenium levels, taking selenium supplements has been linked to a higher chance of developing other autoimmune conditions, including Sjögren's syndrome, over five years.

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Pro

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Against

Evidence from Studies

Supporting (1)

59

Community contributions welcome

59

Clinical Outcomes of Selenium Supplementation in Hashimoto's Thyroiditis Without Selenium Deficiency: A Large‐Scale Retrospective Cohort Study

Cohort Study

Human

2026 May

This study found that giving selenium supplements to people with Hashimoto's thyroiditis—even if they weren't deficient in selenium—made them more likely to develop other autoimmune diseases like Sjögren's syndrome. So, the supplements might be doing more harm than good.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Clinical Outcomes of Selenium Supplementation in Hashimoto's Thyroiditis Without Selenium Deficiency: A Large‐Scale Retrospective Cohort Study

Score: 59

DOI: 10.1002/edm2.70239

Similar Assertions

In people with Hashimoto's thyroiditis who have normal selenium levels, taking selenium supplements daily for six months or longer is linked to sustained increases in thyroid antibodies and hormone levels over five years.

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Among adults with Hashimoto's thyroiditis who have normal selenium levels, taking selenium supplements is linked to a 169% higher relative risk of developing psoriasis over five years.

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Among adults with Hashimoto's thyroiditis who have normal selenium levels, taking selenium supplements may be linked to a 63% higher chance of dying from any cause over five years, even though there is no evidence it increases the risk of thyroid cancer or the need for thyroid surgery.

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In people with Hashimoto's thyroiditis, lower levels of selenium in the blood are linked to higher levels of antibodies that attack the thyroid gland, even when overall selenium levels are not deficient compared to healthy individuals.

35

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In people with Hashimoto’s thyroiditis, taking selenium supplements raises levels of selenium and certain antioxidant proteins in the blood, and these changes are linked to lower levels of thyroid autoantibodies and TSH.

56

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