The Claim
Higher plasma erythritol levels are associated with a significantly increased risk of major adverse cardiovascular events (MACE), including death, nonfatal heart attack, or stroke, in adults undergoing cardiac evaluation, with those in the highest quartile exhibiting an 80% to 121% higher adjusted risk compared to those in the lowest quartile, after controlling for age, diabetes, smoking, and cholesterol levels.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Adults with higher levels of erythritol in their blood have a significantly higher rate of heart attacks, strokes, or death compared to those with lower levels, even when accounting for other known risk factors like age, diabetes, and cholesterol.
See the scientific wording
Higher plasma erythritol levels are associated with a significantly increased risk of major adverse cardiovascular events (MACE), including death, nonfatal heart attack, or stroke, across three independent cohorts of adults undergoing cardiac evaluation, with individuals in the highest quartile of erythritol levels showing an 80% to 121% higher adjusted risk compared to those in the lowest quartile, even after accounting for traditional cardiovascular risk factors such as age, diabetes, smoking, and cholesterol levels.
When erythritol enters the blood, it makes platelets more reactive to signals that trigger clotting. This causes platelets to release more calcium, stick together more easily, and form clots faster inside arteries, which can block blood flow and cause heart attacks or strokes.
What the research says
1 studyStudy: The artificial sweetener erythritol and cardiovascular event risk
People who have more erythritol in their blood—often from eating sugar-free foods—were found to be much more likely to have heart attacks, strokes, or die from heart problems, even when other risks like diabetes were considered. The study also showed erythritol makes blood clot more easily, which could explain why.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.