For adults with knee arthritis and either obesity or type 2 diabetes, taking certain diabetes weight-loss drugs like semaglutide for 6 to 12 months can lead to noticeable weight loss—sometimes over 10% of body weight—with the best results seen using the 2.4 mg weekly dose of semaglutide. This weight loss might also help ease knee pain by improving metabolism.

If you have knee arthritis, taking certain diabetes weight-loss drugs like semaglutide or liraglutide can help you lose around 7.5 kilograms on average, mostly because they help control your hunger and energy use, which might also take some pressure off your joints.

A diabetes drug called semaglutide might help people with knee arthritis lose weight and feel less pain, according to a recent study.

People with knee arthritis and type 2 diabetes who take GLP-1 drugs like semaglutide tend to lose a lot more weight—about 7 extra kilograms—over nearly 8 years compared to those not taking them, and many more of them achieve meaningful weight loss.

If you have diabetes and take GLP-1 drugs like Ozempic for five years, you might be more likely to develop hip or knee arthritis—even if you're not overweight. These meds help with blood sugar and weight, but this claim says they could also hurt your joints over time.

If someone has had weight-loss surgery but isn’t losing enough weight—or gains it back—taking semaglutide seems to help them lose more weight than if they took liraglutide, and they’re over twice as likely to lose 10% or more of their body weight.