If someone has had weight-loss surgery but isn’t losing enough weight—or gains it back—taking semaglutide seems to help them lose more weight than if they took liraglutide, and they’re over twice as likely to lose 10% or more of their body weight.

If someone has had weight-loss surgery but isn’t losing enough weight or gains it back, doctors might prescribe drugs like liraglutide, semaglutide, or tirzepatide. About 27% don’t respond well to liraglutide, 19% to semaglutide, and only 3% to tirzepatide—meaning they don’t lose at least 5% of their body weight.

Semaglutide helps people who are overweight or obese lose weight by making them feel less hungry and slowing down how fast food leaves their stomach.

When a drug like semaglutide turns on certain brain and body signals, it helps people feel fuller, eat less, and lose about 15% of their body weight on average.

If you have knee arthritis, taking certain diabetes weight-loss drugs like semaglutide or liraglutide can help you lose around 7.5 kilograms on average, mostly because they help control your hunger and energy use, which might also take some pressure off your joints.

People who didn’t lose enough weight after weight-loss surgery might lose more with a drug called tirzepatide compared to another drug called semaglutide — about 15.5% vs 10.3% of their body weight in six months.