People who didn’t lose enough weight after weight-loss surgery might lose more with a drug called tirzepatide compared to another drug called semaglutide — about 15.5% vs 10.3% of their body weight in six months.

A new weight-loss drug called tirzepatide might help people with obesity lose about 23% of their body weight in a year and a half — possibly even more than some weight-loss surgeries.

A diabetes drug called tirzepatide can help people lose up to 21% of their body weight, but the weight loss tends to stop increasing too soon — especially for those with type 2 diabetes.

Some diabetes and weight-loss drugs, like tirzepatide, can help people lose a lot of weight—up to nearly 18% more than a fake treatment over a year and a half—especially in those without diabetes, and they might also improve overall health.

If someone has had weight-loss surgery but isn’t losing enough weight or gains it back, doctors might prescribe drugs like liraglutide, semaglutide, or tirzepatide. About 27% don’t respond well to liraglutide, 19% to semaglutide, and only 3% to tirzepatide—meaning they don’t lose at least 5% of their body weight.

If someone has had weight-loss surgery but isn’t losing enough weight—or gains it back—taking semaglutide seems to help them lose more weight than if they took liraglutide, and they’re over twice as likely to lose 10% or more of their body weight.