Some diabetes and weight-loss drugs, like tirzepatide, can help people lose a lot of weight—up to nearly 18% more than a fake treatment over a year and a half—especially in those without diabetes, and they might also improve overall health.

A diabetes drug called tirzepatide can help people lose up to 21% of their body weight, but the weight loss tends to stop increasing too soon — especially for those with type 2 diabetes.

A new weight-loss drug called tirzepatide might help people with obesity lose about 23% of their body weight in a year and a half — possibly even more than some weight-loss surgeries.

A drug called retatrutide probably helps people with obesity or type 2 diabetes lose about 14% of their body weight when given as a weekly shot for up to a year, and higher doses seem to lead to more weight loss.

Losing just 1 kilogram (about 2.2 pounds) of body weight while taking GLP-1 diabetes drugs is linked to a 7% lower chance of having a heart attack, stroke, or dying from heart disease.

A drug called retatrutide helps people lose a lot of weight—sometimes over 70 pounds—by targeting certain hormones, but it works so well that it can cause unexpected health problems.