People with knee arthritis and type 2 diabetes who take GLP-1 drugs (like Ozempic) may be less likely to need knee surgery—only 1.7% did, compared to 5.9% who didn’t take the drugs, over about 8 years.

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Pro

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Evidence from Studies

Supporting (1)

67

Community contributions welcome

67

Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort

Cohort Study

Human

2023 Sep

The study found that diabetic patients with knee arthritis who took GLP-1RAs were much less likely to need knee surgery over nearly 8 years, and this matches the claim.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort

Score: 67

DOI: 10.1136/ard-2023-223845

Similar Assertions

People with knee arthritis and diabetes who take GLP-1 drugs like Ozempic seem to need knee surgery less often — 1.7% of them did over 6 years, compared to 5.9% who didn’t take the drugs — and some of this benefit comes from losing weight.

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93%

If you're obese but don't have diabetes, taking GLP-1 drugs like Ozempic for five years doesn't seem to raise your risk of joint problems like arthritis or needing joint surgery — so if joint issues show up in people with diabetes on these drugs, it might be because of their diabetes, not the drug itself.

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88%

For people with knee arthritis and type 2 diabetes, taking GLP-1 drugs (like Ozempic) may lower the chance of needing knee surgery — and about one-third of that benefit comes from losing weight, not just from better blood sugar control.

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87%

People with knee arthritis and type 2 diabetes who take GLP-1 drugs like Ozempic might lose knee cartilage more slowly, which could help delay joint damage.

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85%

If you have knee arthritis and diabetes, taking GLP-1 drugs like Ozempic might help slow down the wearing away of knee cartilage, according to one study that watched people over time.

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84%