People with type 2 diabetes who have low levels of folate (a B vitamin) in their blood are 43% more likely to die from heart disease than those with moderate folate levels—so low folate might be linked to worse heart outcomes.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Cohort Study

Human

2022 Jan 4

This study found that adults with type 2 diabetes who have very low levels of folate (below 7.1 ng/mL) are much more likely to die from heart disease than those with moderate levels, which is exactly what the claim says.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Score: 59

DOI: 10.1001/jamanetworkopen.2021.46124

Similar Assertions

For people with type 2 diabetes, having higher levels of folate (a B vitamin) in their blood doesn’t seem to make them more likely to die from heart disease, compared to people with moderate folate levels.

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In people with type 2 diabetes, low folate might raise the risk of dying from heart disease because it leads to higher homocysteine, but high vitamin B12 affects heart disease risk on its own, no matter what homocysteine levels are.

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82%