People with ulcerative colitis who have elevated levels of fecal calprotectin before Ramadan fasting are more likely to experience a worsening of their symptoms during the fasting period.

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Pro

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Against

Evidence from Studies

Supporting (1)

33

Community contributions welcome

33

Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depression, and quality of life in patients with inflammatory bowel diseases: A prospective cohort study

Cohort Study

Human

2022 Apr 24

People with UC who already had signs of gut inflammation before fasting were more likely to feel worse during Ramadan fasting, even if their inflammation didn’t get worse on tests. So, higher baseline calprotectin means you’re more at risk for symptoms during fasting.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depression, and quality of life in patients with inflammatory bowel diseases: A prospective cohort study

Score: 33

DOI: 10.1186/s12876-022-02272-3

Similar Assertions

People with ulcerative colitis who fast during Ramadan may experience worse symptoms, but this is not due to increased inflammation in the body, since standard inflammation markers do not change. Other factors like changes in when medications are taken, sleep patterns, or diet may be responsible.

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92%

In people with ulcerative colitis or Crohn’s disease, fasting during Ramadan for one month does not lead to measurable changes in two biomarkers of inflammation: C-reactive protein in the blood and calprotectin in the stool.

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91%

In patients with ulcerative colitis, fasting during Ramadan for 14 to 15 hours per day is linked to a small but measurable increase in disease activity symptoms, especially in individuals aged 30 or older or those with higher baseline levels of fecal calprotectin, without corresponding changes in blood or stool markers of inflammation.

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90%

During Ramadan fasting, people with ulcerative colitis may experience worsening symptoms, while those with Crohn’s disease typically do not show a change in symptoms, suggesting that fasting affects these two conditions differently.

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86%

In people with Crohn’s disease, fasting during Ramadan does not lead to measurable changes in blood markers of inflammation or symptom severity over one month.

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83%