People with worse Alzheimer's disease tend to have lower levels of a substance in their blood that's linked to how well blood flows in the brain and body — and the sicker they are, the lower those levels get.

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Evidence from Studies

Supporting (1)

43

Community contributions welcome

43

Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease

Cross-Sectional Study

Human

2018

The study found that as Alzheimer’s gets worse, the body makes less of a chemical (nitrate) that helps blood vessels stay open, and blood flow drops everywhere — in the brain and limbs — which matches exactly what the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease

Score: 43

DOI: 10.3389/fphys.2018.00169

Similar Assertions

In people with Alzheimer’s, blood flow problems in the brain, head, and body get worse as the disease gets worse, and this seems to be tied to a chemical in the blood called nitric oxide—meaning the whole body’s blood vessels might be failing together, not just the brain.

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People with Alzheimer’s might have blood vessel problems for reasons other than just low nitric oxide — something else could be going on too.

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People with Alzheimer's have blood vessels that don't respond as well to signals that make them open up, even after taking a supplement called nitrate—which normally helps blood flow better—compared to older healthy people and young people.

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