Claim
mechanistic
Peptide antibiotics can tell the difference between bacterial and human cells because they have different electrical charges - bacteria have negatively charged membranes while human cells are neutral.
Evidence from Studies
No evidence studies found yet.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
1
Case-Control Studies
Comparative analysis of AMP binding to bacterial vs mammalian cell membranes
Case-control study comparing AMP binding affinity and cytotoxicity in bacterial cells (e.g., MRSA, E. coli) versus mammalian cells (e.g., human fibroblasts, kidney cells) using fluorescent labeling and membrane potential assays