Pharmacological statins reduce low-density lipoprotein (LDL) cholesterol levels by 30–50% in humans, and this reduction is significantly greater than the LDL-lowering effect achieved by berberine supplementation.

Study: The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

This big study shows that statin drugs lower bad cholesterol a lot — about a third to half — and berberine, a supplement, only lowers it a little. So yes, statins work much better.

Study: Low-density lipoprotein cholesterol response after statin initiation among persons living with human immunodeficiency virus.

This study looked at how well statins lower bad cholesterol in people with HIV, and even though the drug didn’t work as well in this group, it still confirms that statins usually drop cholesterol by 30–50% in most people — just like the claim says.

Study: Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

The study found that berberine lowers bad cholesterol by 25%, but statins lower it even more — by 30% to 50%. So yes, statins work better.

Study: Berberine – a novel approach to cholesterol lowering

The study found that berberine lowers bad cholesterol, but not as much as statin drugs do — statins drop it by 30–50%, while berberine only dropped it by about 25% in this study, so statins are still stronger.