Platelets use a receptor called GPVI to grab onto collagen through specific amino acid patterns (GPO), which starts the blood clotting process to stop bleeding.
Scientific Claim
GPVI on platelets binds collagen via GPO motifs, triggering platelet activation and thrombus formation.
Original Statement
“Glycoprotein VI (GPVI) is an immunoglobulin-based transmembrane stimulatory receptor that is expressed in megakaryocytes and platelets and specifically binds with Gly-Pro-Hyp amino acid residues of collagen. Collagen triggers platelet activation by phosphorylation of downstream signal molecules of the collagen-specific receptor GPVI signal pathway, including ITAM-Syk, PLCy2, and PI3K-Akt-GSK3β, which is inhibited by αIIbβ3-mediated β3-Src signals.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The binding and activation mechanism is experimentally validated in multiple studies, supporting definitive language.
Evidence from Studies
Supporting (1)
The Molecular Interaction of Collagen with Cell Receptors for Biological Function