Taking rapamycin with exercise might help improve muscle strength in older people by affecting a specific cell pathway in the body.

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Evidence from Studies

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Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA‐EX‐01 Randomised, Double‐Blind, Placebo‐Controlled Trial

Randomized Controlled Trial

Human

2026 Apr

A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program

Randomized Controlled Trial

Human

2024 Oct 1

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Similar Assertions

Older mice with overactive mTORC1 had higher levels of certain muscle-related amino acid processes after taking rapamycin, which might help muscles handle stress and stay healthy.

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Taking a weekly 6 mg dose of rapamycin might actually slow down strength gains in older people who are working out, even though both those on and off the drug get a bit stronger.

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Rapamycin might help older animals keep their muscle and stay lean by tweaking a key cell signal involved in aging.

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Taking rapamycin between workouts might help your muscles clean out junk and rebuild stronger as you age — like getting the best of both rest and exercise.

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Giving older mice a drug called rapamycin helps keep their muscles strong and working well as they age, especially in some muscles but not others.

81%