Rat bone-building cells have special spots inside their control centers that grab thyroid hormone very tightly, and each cell has room for about 2,000 of these hormone connections.

3

Pro

0

Against

Evidence from Studies

Supporting (1)

3

Community contributions welcome

3

Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3'-triiodo-L-thyronine nuclear receptors.

Cross-Sectional Study

In Vitro

1987 May

The study looked at how thyroid hormone binds to receptors in rat bone cells and found exactly what the claim says: there are specific receptors that strongly bind T3, with the same strength and number as stated.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3'-triiodo-L-thyronine nuclear receptors.

Score: 3

DOI: 10.1210/ENDO-120-5-1873

Similar Assertions

In rat bone cells, how strongly different thyroid hormones stick to their receptors matches how active they're known to be — suggesting these receptors actually do something important in how thyroid hormones affect bones.

3

0

89%

Thyroid hormones seem to turn up the activity of a bone-building enzyme in rat bone cells, even at low levels—kind of like a volume knob for bone growth.

3

0

74%