In rat bone cells, how strongly different thyroid hormones stick to their receptors matches how active they're known to be — suggesting these receptors actually do something important in how thyroid hormones affect bones.

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Evidence from Studies

Supporting (1)

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Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3'-triiodo-L-thyronine nuclear receptors.

Cross-Sectional Study

In Vitro

1987 May

The study shows that how well different thyroid hormones stick to receptors in rat bone cells matches how strong their effects are, which supports the idea that these receptors are important for how thyroid hormones affect bone.

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Source Study

Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3'-triiodo-L-thyronine nuclear receptors.

Score: 3

DOI: 10.1210/ENDO-120-5-1873

Similar Assertions

Rat bone-building cells have special spots inside their control centers that grab thyroid hormone very tightly, and each cell has room for about 2,000 of these hormone connections.

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89%

Thyroid hormones seem to turn up the activity of a bone-building enzyme in rat bone cells, even at low levels—kind of like a volume knob for bone growth.

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76%