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Strong Support
causal
Analysis v1
History

Rats fed a diet high in linoleic acid after birth show increased levels of two specific endocannabinoid molecules in their blood as adults. Female rats start with higher baseline levels of these molecules, and the effect of the diet on one of them, 2-AG, differs between males and females.

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Evidence from Studies

Supporting (1)

13

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13

Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets

Cohort Study
Animal
2024 Jul 19

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Source Study

Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets

Score: 13
DOI: 10.3390/ijms25147911

Similar Assertions

When mother rats consume a diet high in linoleic acid, their male offspring show changes in brain fat composition, including increases in arachidonic acid and certain plasmalogen markers, and decreases in oleate and nervoniate, which may relate to changes in brain inflammation processes.

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