Rats on a low-protein, high-carb diet had less of the special proteins in their fat cells that are needed to burn fat, which might explain why their fat isn't being broken down.

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Evidence from Studies

Supporting (1)

9

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9

In Vitro TNF-α- and Noradrenaline-Stimulated Lipolysis is Impaired in Adipocytes from Growing Rats Fed a Low-Protein, High-Carbohydrate Diet

Cohort Study

Animal

2013 Aug

The study fed rats a diet low in protein and high in carbs and found that their fat cells stopped making the proteins needed to break down fat — exactly what the claim says.

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Source Study

In Vitro TNF-α- and Noradrenaline-Stimulated Lipolysis is Impaired in Adipocytes from Growing Rats Fed a Low-Protein, High-Carbohydrate Diet

Score: 9

DOI: 10.1007/s11745-013-3809-z

Similar Assertions

Even though the rats had high levels of stress hormones that should make them burn fat, their fat cells had less activity in a key signaling pathway (ERK), which might be why they kept storing fat instead.

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