Even though the rats had high levels of stress hormones that should make them burn fat, their fat cells had less activity in a key signaling pathway (ERK), which might be why they kept storing fat instead.

9

Pro

0

Against

Evidence from Studies

Supporting (1)

9

Community contributions welcome

9

In Vitro TNF-α- and Noradrenaline-Stimulated Lipolysis is Impaired in Adipocytes from Growing Rats Fed a Low-Protein, High-Carbohydrate Diet

Cohort Study

Animal

2013 Aug

Rats fed a low-protein, high-carb diet had trouble breaking down fat, even though their bodies were in a state that should make them burn fat. The study found this was because a key signaling pathway (ERK) in their fat cells was turned down, which explains why they kept storing fat instead of burning it.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

In Vitro TNF-α- and Noradrenaline-Stimulated Lipolysis is Impaired in Adipocytes from Growing Rats Fed a Low-Protein, High-Carbohydrate Diet

Score: 9

DOI: 10.1007/s11745-013-3809-z

Similar Assertions

Rats on a low-protein, high-carb diet had less of the special proteins in their fat cells that are needed to burn fat, which might explain why their fat isn't being broken down.

9

0

73%

Rats that ate a diet low in protein and high in carbs had fat cells that didn't break down fat as well when stimulated by certain stress signals, even though their bodies were in a state that should make them burn fat.

9

0

72%