Rats that ate a diet low in protein and high in carbs had fat cells that didn't break down fat as well when stimulated by certain stress signals, even though their bodies were in a state that should make them burn fat.

9

Pro

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Against

Evidence from Studies

Supporting (1)

9

Community contributions welcome

9

In Vitro TNF-α- and Noradrenaline-Stimulated Lipolysis is Impaired in Adipocytes from Growing Rats Fed a Low-Protein, High-Carbohydrate Diet

Cohort Study

Animal

2013 Aug

Rats fed a diet low in protein and high in carbs couldn't break down fat as well when their bodies tried to signal them to do so, like when they're under stress. The study shows their fat cells just don't respond properly to those signals.

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No contradicting evidence found

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Source Study

In Vitro TNF-α- and Noradrenaline-Stimulated Lipolysis is Impaired in Adipocytes from Growing Rats Fed a Low-Protein, High-Carbohydrate Diet

Score: 9

DOI: 10.1007/s11745-013-3809-z

Similar Assertions

Even though their bodies were sending out signals to burn fat (like stress hormones), the fat cells of rats on a low-protein, high-carb diet ignored those signals and kept storing fat instead.

9

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75%

Even though the rats had high levels of stress hormones that should make them burn fat, their fat cells had less activity in a key signaling pathway (ERK), which might be why they kept storing fat instead.

9

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72%