When rats consume sodium oleate, they learn to avoid the taste of it, suggesting the compound causes a physiological discomfort similar to illness, not just fullness. Free oleic acid does not produce...
Mechanism
Synthesis from 1 study
Sodium oleate makes rats feel sick because it triggers special sensors in their intestines that send a 'you're unwell' signal to the brain. Free oleic acid doesn't do this, so it doesn't make them avoid tastes. The difference in how these two molecules behave in the gut explains why only one causes...
Most probable mechanism
When sodium oleate enters the intestine, it triggers special sensors that send signals to the brain, making the animal feel sick. This causes the animal to avoid any taste it recently experienced, like sweetness. Free oleic acid doesn’t trigger this response, so it doesn’t cause sickness.
Sodium oleate is detected by chemosensory receptors in the intestinal lumen, activating afferent neural pathways.
Activation of these pathways leads to signaling in brainstem regions associated with nausea and aversion learning.
This neural signaling results in conditioned avoidance of a previously paired taste stimulus.
Evidence from Studies
Supporting (1)
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Satiety from fat? Adverse effects of intestinal infusion of sodium oleate.
Contradicting (0)
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