The Claim

In both normal and uraemic erythrocytes, the intracellular concentration of creatine is approximately 10 times higher than in plasma and remains independent of plasma creatine levels, indicating that active, saturable transport mechanisms are responsible for maintaining intracellular creatine homeostasis.

Source: Regulation of intracellular creatine in erythrocytes and myoblasts: Influence of uraemia and inhibition of Na, K‐ATPase

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
27score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Red blood cells keep much more creatine inside them than is floating in the blood, even if blood levels change — it’s like they have a special pump that keeps the levels steady.

See the scientific wording

In both normal and uraemic erythrocytes, intracellular creatine concentration is approximately 10 times higher than in plasma, and does not depend on plasma creatine levels, suggesting active, saturable transport maintains intracellular creatine homeostasis.

What the research says

1 study

  1. Study: Regulation of intracellular creatine in erythrocytes and myoblasts: Influence of uraemia and inhibition of Na, K‐ATPase

    The study found that red blood cells keep their creatine levels much higher than in the blood, no matter how much creatine is in the blood, which means they actively control it — just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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