Replacing one specific amino acid in the GLP-1 hormone with a modified version prevents it from breaking down quickly in human blood, allowing it to last more than 12 hours instead of 6–7 hours like...
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Evidence from Studies
Supporting (1)
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Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.
Randomized Controlled Trial
Animal & In Vitro
2004 Aug 15Contradicting (0)
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No contradicting evidence found
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