A once-a-week shot called retatrutide may help lower blood sugar levels in people who are overweight, obese, or have type 2 diabetes—even if they don’t lose weight.

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

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69

Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: A systematic review and meta-analysis of randomized controlled trials

Systematic Review With Meta-Analysis

Human

2024 Dec

The study shows that the drug helps people lose weight and may improve some blood sugar-related things, but it doesn’t say anything about the exact numbers for HbA1c and fasting glucose that the claim mentions, so we can’t say the claim is proven.

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: A systematic review and meta-analysis of randomized controlled trials

Score: 69

DOI: 10.1016/j.metop.2024.100321

Similar Assertions

People who get a weekly shot of a new medicine called retatrutide are about 18 times more likely to lose at least 15% of their body weight than those who get a placebo, which could mean a lot of them reach a weight loss level that really improves their health.

69

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Taking a weekly injection called retatrutide might help people who are overweight or have type 2 diabetes lose around 10-11 pounds, shrink their waistline, and lower their BMI — which could mean real, helpful weight loss.

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Taking a weekly shot of a drug called retatrutide might help lower blood pressure in people who are overweight, obese, or have type 2 diabetes — and this benefit might happen even if they don’t lose much weight.

0

69

78%