People with obesity and knee pain from arthritis who took a drug called retatrutide lost nearly a third of their body weight and felt much less pain—showing it might help both their weight and joint issues.

People with obesity who took a shot called retatrutide once a week for a year lost nearly a quarter of their body weight—way more than those who got a dummy shot. This makes it one of the strongest weight-loss medicines we’ve seen so far.

Most people with obesity who take a high dose of a drug called retatrutide every week for nearly a year lose at least 15% of their body weight — that’s like dropping 30 pounds if you weigh 200. Almost no one on a fake pill loses that much.

People who get a weekly shot of a new medicine called retatrutide are about 18 times more likely to lose at least 15% of their body weight than those who get a placebo, which could mean a lot of them reach a weight loss level that really improves their health.

Taking a drug called retatrutide every week for about 6 to 12 months probably helps people with obesity or type 2 diabetes lose belly fat and drop their BMI by noticeable amounts.