Scientists found that a lab-grown type of immune cell (called THP-1) acts like the immune cells from pregnant women with preeclampsia — it shows the same signs of inflammation. This makes it a useful tool for studying the condition without using human patients.

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Evidence from Studies

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Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Cross-Sectional Study

Human

2021 Apr

Scientists found that immune cells from women with preeclampsia show a specific inflammation pattern, and lab-grown THP-1 cells behave the same way when triggered—so THP-1 cells are a good stand-in for studying this condition in the lab.

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Source Study

Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Score: 42

DOI: 10.1016/j.jri.2021.103286

Similar Assertions

When women have preeclampsia during pregnancy, their immune cells called monocytes are more active and produce more inflammatory signals than those in pregnant women without this condition, suggesting their bodies are in a constant low-level inflammatory state.

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When scientists test immune cells from pregnant women with a condition called preeclampsia, adding progesterone or vitamin D to the cells in a lab seems to calm down their inflammation. It’s like turning down the volume on the body’s alarm system.

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In women with a pregnancy complication called preeclampsia, a substance called hyaluronan makes immune cells more inflamed, but two other substances—progesterone and vitamin D—can calm that inflammation down in lab tests.

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