A natural compound called THBru might stick directly to a key energy sensor in liver cells, and scientists saw this happen in lab tests using mouse livers and human liver cells in a dish.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway.

Cohort Study

Animal

2025 Feb 15

Scientists found that THBru, a compound they studied, sticks directly to AMPK, a key protein in liver cells, just like a key fits into a lock — and this was proven using two reliable lab methods.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway.

Score: 7

DOI: 10.1016/j.ejphar.2024.177228

Similar Assertions

Scientists think a compound called THBru might help the body burn fat better by activating a natural 'metabolism switch' called AMPK, and they saw this happen in mouse livers and human liver cells in a dish.

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