A natural compound called THBru may help lower bad cholesterol by turning down genes that block cholesterol removal and turning up the gene that helps the liver pull cholesterol out of the blood.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway.

Cohort Study

Animal

2025 Feb 15

The study found that THBru, a compound derived from berberine, helps lower bad cholesterol by turning down two proteins (SREBP2 and PCSK9) that block cholesterol removal and turning up the LDL receptor that clears cholesterol from the blood — exactly what the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway.

Score: 7

DOI: 10.1016/j.ejphar.2024.177228

Similar Assertions

A natural compound called THBru helps liver cells lower bad cholesterol by turning on a specific cellular switch (AMPK), but if you block that switch, THBru can't do its job anymore.

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Scientists think a compound called THBru might help the body burn fat better by activating a natural 'metabolism switch' called AMPK, and they saw this happen in mouse livers and human liver cells in a dish.

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A natural compound called THBru might stick directly to a key energy sensor in liver cells, and scientists saw this happen in lab tests using mouse livers and human liver cells in a dish.

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Giving a natural compound called THBru to mice that eat a lot of fat helps their livers stay healthier and better manage fats in their blood.

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