The kidney benefits from taking a weekly semaglutide shot for weight and heart health probably aren't just because it lowers blood sugar or blood pressure — there might be other ways it's helping the...

For adults who are overweight, have heart disease, and early kidney problems but not diabetes, taking a weekly semaglutide shot might help their kidneys work better over two years compared to a placebo.

In adults with type 2 diabetes and advanced kidney disease, a weekly injection of semaglutide at 1.0 mg lowers the combined risk of kidney failure, severe loss of kidney function, or death from heart or kidney causes by 24% compared to a placebo over about 3.4 years.

Taking a weekly semaglutide shot might help protect the kidneys in people with extra weight and heart disease—even if they don’t have diabetes.

For people with type 2 diabetes and kidney problems, taking a weekly semaglutide shot might help slow down how fast their kidneys get worse.

In adults with type 2 diabetes and kidney disease, a weekly injection of semaglutide at 1.0 mg lowers the combined risk of severe kidney function decline, kidney failure, or death from kidney or heart causes by 24% compared to a placebo over about 3.4 years, regardless of whether they were already taking mineralocorticoid receptor antagonists.