For adults who are overweight, have heart disease, but don’t have diabetes, taking a weekly semaglutide shot might help slow down how fast their kidneys lose function each year.

For adults who are overweight, have heart disease, and early kidney problems but not diabetes, taking a weekly semaglutide shot might help their kidneys work better over two years compared to a placebo.

Taking a weekly semaglutide shot (2.4 mg) for about a year and a half can help lower blood pressure, blood sugar, bad cholesterol, and body-wide inflammation in adults with extra weight but no diabetes—better than a placebo.

In people with type 2 diabetes and kidney disease, a weekly injection of semaglutide at 1.0 mg slows the rate at which kidney function declines by 1.16 mL/min/1.73m² per year compared to no treatment, based on a median follow-up of 3.4 years.

In adults with type 2 diabetes and advanced kidney disease, a weekly injection of semaglutide at 1.0 mg lowers the combined risk of kidney failure, severe loss of kidney function, or death from heart or kidney causes by 24% compared to a placebo over about 3.4 years.

Taking a weekly semaglutide shot (2.4 mg) for about a year helps people with extra weight feel more physically capable and improves their overall quality of life—more than a dummy pill would.