Six chemical compounds, including two approved medications, can block the human DIO2 enzyme in a test tube, reducing its ability to convert the thyroid hormone T4 into the active form T3, with some...

Evidence from Studies

Supporting (1)

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Novel Deiodinase 2-Selective Inhibitors—Possible Reference Substances for Regulatory In Vitro Tests for Endocrine Disruptors and Drugs Targeting T3-Dependent Processes

Computational/Algorithm Study

In Vitro

2026 Apr

Contradicting (0)

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No contradicting evidence found

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Source Study

Novel Deiodinase 2-Selective Inhibitors—Possible Reference Substances for Regulatory In Vitro Tests for Endocrine Disruptors and Drugs Targeting T3-Dependent Processes

DOI: 10.1177/10507256261425689