Not getting enough sleep can cause your whole body to become inflamed, which may increase your risk of heart and blood vessel problems. This harmful effect happens even if you take melatonin supplements to help you rest.

Long-term poor sleep and insomnia raise your chances of heart problems by triggering body-wide inflammation. This same inflammation might also mess up research trying to figure out if melatonin supplements are bad for your heart.

Taking melatonin supplements appears to lower markers of inflammation in the body, such as CRP and IL-6. This reduction in inflammation might help protect the heart, especially for people who already have ongoing, low-level inflammation.

People with heart disease, metabolic issues, or sleep problems often have lower levels of melatonin, the body's natural sleep hormone. This drop might be caused by aging, poor sleep cycles, or long-term inflammation, and boosting melatonin back to normal levels could potentially help slow down these health conditions.

Taking 10 milligrams or more of melatonin every day for at least three months may help lower your body's overall inflammation levels. This happens because the supplement might block a specific cellular switch that normally triggers inflammatory chemicals like IL-6 and TNF-alpha.

Staying awake all at once doesn't actually change your stress hormones, blood pressure, or heart rate the next day if you're a healthy young adult in a relaxed setting. This means that just losing a night of sleep won't automatically spike your body's stress response unless you're also under other pressures.