Analysis Version
v1
History
Back to Study: 'That's the Esketamine, Baby, there's Nothing You ...
descriptive
Analysis v1
20
Pro
0
Against

Some studies show that a nasal spray called esketamine helps with severe depression, but other bigger studies don’t show the same level of help—so scientists are confused about whether it really works as well as first thought.

Claim Language

Language Strength

association

Uses association language (linked to, correlated with)

The claim uses 'reported discrepancies,' which indicates an observation or pattern noted in data without asserting causation or certainty. 'Reported' implies findings from studies, and 'discrepancies' suggests a difference observed, not proven.

Context Details

Domain

medicine

Population

human

Subject

the efficacy of intranasal esketamine

Action

are reported discrepancies in

Target

between phase II and phase III clinical studies in patients with treatment-resistant or major depressive disorder

Intervention Details

Type: pharmacological

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Evidence from Studies

Supporting (1)

20
20

'That's the Esketamine, Baby, there's Nothing You Can Do about It!' An Update on Glutamatergic System in Suicidal Depression.

Systematic Review
Human
2020

The study says that in early tests, the nasal spray worked well, but in later, bigger tests, the results weren’t as consistent — which is exactly what the claim is saying.

Contradicting (0)

0
No contradicting evidence found

Source Study

'That's the Esketamine, Baby, there's Nothing You Can Do about It!' An Update on Glutamatergic System in Suicidal Depression.

Score: 20
DOI: 10.2174/1568026620666200131100316

Similar Assertions

For people with depression that hasn’t responded to other treatments, using a nasal spray called esketamine for six months may significantly help lift their mood, based on standard depression scores.

31
0
90%

For people with depression that hasn’t responded to other treatments, a nasal spray called esketamine helps a little bit — and it works about as well as adding another type of psychiatric medication.

33
0
88%

In two people with severe depression that didn’t improve with other treatments, their symptoms got worse when their esketamine nose spray was given twice a week instead of once a week.

20
0
88%

We don’t yet know if a nasal spray called esketamine is safe and works well over a long time for people with severe depression who are at risk of suicide—more research is needed.

20
0
87%

When people with severe depression that hasn’t responded to regular antidepressants get a nasal spray called esketamine along with their usual meds, they tend to feel a little better after a few weeks—about as much as if they added a different type of psychiatric pill.

33
0
87%