The Claim

Genetic variants in the MSTN, IGF-1, and B2BRK genes are associated with small differences in muscle hypertrophy response to resistance training, but collectively account for only a minor proportion of the inter-individual variation observed between high and low responders.

Source: Physiological Differences Between Low Versus High Skeletal Muscle Hypertrophic Responders to Resistance Exercise Training: Current Perspectives and Future Research Directions

What the research says

Roughly balanced

Support and challenge are close. The picture may shift as more studies come in.

Supports
1score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Some people’s genes might make them build a little more muscle from weight training than others, but these specific genes don’t explain much of why some people get way stronger than others.

See the scientific wording

Genetic variants in genes such as MSTN, IGF-1, and B2BRK are associated with small differences in muscle hypertrophy response to resistance training, but collectively explain only a minor portion of the variation seen between high and low responders.

What the research says

1 study

  1. Study: Physiological Differences Between Low Versus High Skeletal Muscle Hypertrophic Responders to Resistance Exercise Training: Current Perspectives and Future Research Directions

    The study found that even though some people have different versions of genes like MSTN and IGF-1, those differences don’t explain much of why some people grow much more muscle than others from weight training—other factors matter more.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.