Some older people don’t build muscle no matter how much they train—and their muscles don’t show any detectable biological changes, even when they do more exercise.
Scientific Claim
Low responders to resistance training show no measurable molecular changes in any pathways, regardless of whether they perform one or four sets of training.
Original Statement
“Low responders, on the other hand, did not show measurable changes in any molecular pathways, regardless of RT volume manipulation.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim is based on direct observation of molecular data across conditions; 'did not show measurable changes' is a conservative, accurate description.
More Accurate Statement
“Low responders to resistance training show no measurable changes in molecular pathways regardless of training volume.”
Evidence from Studies
Supporting (1)
Molecular signatures underlying heterogenous hypertrophy responsiveness to resistance training in older men and women: a within-subject design.
Even when low responders did more workouts, their muscles didn’t show any biological changes—unlike others who responded well. So, doing more sets didn’t help them at the molecular level.