Some older people don’t build muscle no matter how much they train—and their muscles don’t show any detectable biological changes, even when they do more exercise.

41

Pro

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Against

Evidence from Studies

Supporting (1)

41

Community contributions welcome

41

Molecular signatures underlying heterogenous hypertrophy responsiveness to resistance training in older men and women: a within-subject design.

Randomized Controlled Trial

Human

2025 Sep 1

Even when low responders did more workouts, their muscles didn’t show any biological changes—unlike others who responded well. So, doing more sets didn’t help them at the molecular level.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Source Study

Molecular signatures underlying heterogenous hypertrophy responsiveness to resistance training in older men and women: a within-subject design.

Score: 41

DOI: 10.1152/japplphysiol.00052.2025

Similar Assertions

This study didn't check how hard you work out, how close you get to max effort, or which exercises you pick — so we can't say for sure how those things affect muscle growth or strength.

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