Statins do not resolve underlying metabolic dysfunction, chronic inflammation, or insulin resistance, which are primary drivers of cardiovascular disease.

Study: Effect of 24 weeks of statin therapy on systemic and vascular inflammation in HIV-infected subjects receiving antiretroviral therapy.

Statins lowered one specific blood vessel inflammation marker but didn't touch other major signs of body-wide inflammation or metabolic problems. So they don't fix the root causes of heart disease — just one piece of the puzzle.

Study: Rosuvastatin reduces vascular inflammation and T cell and monocyte activation in HIV-infected subjects on antiretroviral therapy

This study shows that a statin drug reduces inflammation and immune system overactivity in people with HIV, even though it doesn’t fix their underlying metabolic problems. So yes, statins help with some symptoms like swelling and immune chaos, but they don’t cure the root causes like insulin resistance.

Study: Statins are associated with increased insulin resistance and secretion

This study found that taking a common cholesterol drug (statin) made people’s bodies worse at using insulin, which is a key problem that leads to heart disease. So, the drug doesn’t fix the root cause — it might even make it worse.

Study: Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner.

Statins lower cholesterol but make blood sugar worse by changing gut bacteria, and this study shows they don’t fix the root metabolic problems that cause heart disease — they might even make them worse.