Statins seem to trigger a cellular cleanup process in the liver that accidentally makes the liver produce more sugar.

Pro

Against

Evidence from Studies

Supporting (1)

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Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction

Cohort Study

Animal & In Vitro

2015 Nov 2

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction

Score: 6

DOI: 10.1080/15548627.2015.1091139

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Taking statins long-term may make the body less responsive to insulin, because the liver keeps making too much sugar thanks to a cellular cleanup process.

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In mice that are overweight and have insulin problems, statins make their livers more active in making sugar, which worsens high blood sugar and insulin resistance.

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Taking statins for a long time may cause the liver to make more sugar, which can raise blood sugar levels.

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