Taking statins long-term may make the body less responsive to insulin, because the liver keeps making too much sugar thanks to a cellular cleanup process.

Pro

Against

Evidence from Studies

Supporting (1)

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Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction

Cohort Study

Animal & In Vitro

2015 Nov 2

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

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Source Study

Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction

Score: 6

DOI: 10.1080/15548627.2015.1091139

Similar Assertions

In mice that are overweight and have insulin problems, statins make their livers more active in making sugar, which worsens high blood sugar and insulin resistance.

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Statins seem to trigger a cellular cleanup process in the liver that accidentally makes the liver produce more sugar.

80%

Taking statins for a long time may cause the liver to make more sugar, which can raise blood sugar levels.

77%