Studies show mixed results on whether doing more resistance training sets leads to more muscle growth in people who already train regularly. Some findings suggest that increasing the number of sets...
Mechanism
Synthesis from 1 study
After years of lifting, muscles get used to the workout and don't grow much more even if you do more sets — they're already working near their max capacity. It's not that the training doesn't work anymore, but the body has adapted and can't respond as strongly to extra stress.
Most probable mechanism
When someone has been lifting weights for a long time, their muscles get used to the stress and don't respond as strongly to more sets — like a sponge that's already full and can't soak up more water, even if you pour more on it.
Chronic resistance training leads to elevated baseline levels of muscle protein synthesis and mTOR pathway activation.
Further increases in training volume fail to significantly elevate anabolic signaling beyond a plateau due to receptor desensitization or feedback inhibition.
Muscle fibers reach a limit in their capacity to incorporate new myofibrillar proteins, limiting hypertrophic response despite increased mechanical load.
Evidence from Studies
Supporting (1)
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Contradicting (0)
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Gold Standard Evidence Needed
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