The Claim
Sulforaphane reduces the expression and activity of cytochrome P450 3A4 in human primary hepatocytes by antagonizing the steroid and xenobiotic receptor (SXR/hPXR), which normally induces this enzyme in response to xenobiotics.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Sulforaphane decreases the levels and function of the liver enzyme cytochrome P450 3A4 by blocking the receptor that activates this enzyme when the body encounters foreign substances.
See the scientific wording
Sulforaphane reduces the expression and activity of cytochrome P450 3A4 in human primary hepatocytes by antagonizing the steroid and xenobiotic receptor (SXR/hPXR), which normally induces this enzyme in response to xenobiotics.
Sulforaphane binds to a liver receptor that normally turns on a drug-processing enzyme, preventing the receptor from activating the gene for that enzyme. Without activation, the enzyme is not made in large amounts, so the liver breaks down fewer drugs.
What the research says
1 studySulforaphane, a compound in broccoli, blocks a liver receptor that normally tells the body to make more of a drug-breaking enzyme. This means the enzyme makes less, so drugs might stay in the body longer.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.