Your body needs to keep turning on a protein called PPARα for a long time to grow more energy factories in your cells and get better at burning fat over the long haul.

Turning on a protein called PPARα helps cells move fat into tiny energy factories (mitochondria) so it can be burned for fuel.

Fructose turns down the liver’s main switch (PPARα) that tells the body to burn fat, and it also reduces the level of a critical enzyme (CPT1α) needed to get fat into the mitochondria to be burned.

Turning on a protein called AMPK tells another protein, PPARα, to switch on genes that help the body burn fat for energy.

Acetic acid might help liver cells burn fat better by turning on certain fat-burning genes, especially when used at a specific amount in lab studies.

Treating rat liver cells with low doses of acetic acid boosts genes and proteins that help burn fat, suggesting these cells might get better at breaking down fats.