The Claim

Six weeks of daily supplementation with 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid significantly improves YES reaction time by 28.7% and overall reaction time by 18.1% in healthy, recreationally active adults aged 26–55.

Source: Effects of 6 weeks of high-dose creatine monohydrate supplementation with or without guanidinoacetic acid on cognitive function

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
68score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

In healthy adults aged 26–55 who are recreationally active, daily intake of 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid for six weeks reduces reaction time in cognitive tasks by 28.7% for YES responses and by 18.1% for overall responses.

See the scientific wording

Six weeks of daily supplementation with 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid significantly improves YES reaction time by 28.7% and overall reaction time by 18.1% in healthy, recreationally active adults aged 26–55, suggesting that combined supplementation enhances speed of response in cognitive tasks requiring rapid decision-making.

Why this might work

Taking creatine and guanidinoacetic acid every day for six weeks increases the amount of high-energy fuel in brain cells. When the brain needs to make quick decisions, this extra fuel lets it recharge its energy supply faster, so neurons can fire and communicate more rapidly, leading to quicker reaction times.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Effects of 6 weeks of high-dose creatine monohydrate supplementation with or without guanidinoacetic acid on cognitive function

    This study found that adults who took 10 grams of creatine and 2 grams of another chemical every day for six weeks got faster at answering simple yes-or-no questions on a computer test. Their reaction times improved significantly, just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.