The Claim
Six weeks of creatine monohydrate supplementation at 10 g/day in healthy adults reduces homocysteine levels by approximately 1.3 µmol/L, and this reduction is not observed when creatine monohydrate is combined with guanidinoacetic acid.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking 10 grams of creatine monohydrate daily for six weeks lowers homocysteine levels by about 1.3 micromoles per liter in healthy adults. This reduction does not occur when creatine is taken with guanidinoacetic acid.
See the scientific wording
Six weeks of creatine monohydrate supplementation (10 g/day) in healthy adults significantly reduces homocysteine levels by approximately 1.3 µmol/L, suggesting a potential beneficial effect on this cardiovascular risk marker, though the effect is not observed when combined with guanidinoacetic acid.
When creatine is made in large amounts, the body uses more methyl groups that would otherwise turn homocysteine into methionine. This pulls homocysteine out of the bloodstream and lowers its levels. When another compound is added that also needs methyl groups, creatine can't pull enough away, so homocysteine stays high.
What the research says
1 studyTaking 10 grams of creatine daily for six weeks slightly lowered a blood marker linked to heart disease in healthy people, and this effect went away when they also took another compound called GAA.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.