The Claim
Six weeks of high-dose creatine monohydrate supplementation (10 g/day) increases serum creatinine levels by approximately 0.08 mg/dL in healthy adults, with this change being statistically significant but remaining within normal physiological ranges and not indicating kidney dysfunction.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking 10 grams of creatine monohydrate daily for six weeks raises serum creatinine levels by about 0.08 mg/dL in healthy adults. This increase is statistically significant but stays within the normal range seen in healthy individuals and does not signal kidney damage.
See the scientific wording
Six weeks of high-dose creatine monohydrate supplementation (10 g/day) increases serum creatinine levels by approximately 0.08 mg/dL in healthy adults, a change that is statistically significant but remains within normal physiological ranges and does not indicate kidney dysfunction.
When extra creatine is taken, the body naturally converts some of it into creatinine by losing a water molecule. This creatinine enters the bloodstream, raising its level without any kidney damage.
What the research says
1 studyTaking 10 grams of creatine daily for six weeks slightly raises a blood marker called creatinine, but this is just because your body is processing the creatine—it doesn’t mean your kidneys are hurt. The study shows this small change is normal and harmless.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.