The Claim
A 10-day supplementation with 100 mg/kg/day of L-citrulline has no effect on time to exhaustion during high-intensity cycling at 75% of maximal power output in healthy, moderately active adults aged 18–35.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking L-citrulline for 10 days at a dose of 100 mg per kilogram of body weight does not change how long healthy, moderately active adults aged 18–35 can cycle at 75% of their maximum power before becoming exhausted.
See the scientific wording
A 10-day supplementation with 100 mg/kg/day of L-citrulline does not improve time to exhaustion during high-intensity cycling at 75% of maximal power output in healthy, moderately active adults aged 18–35, indicating no ergogenic benefit for this specific endurance protocol under these conditions.
L-citrulline is converted into arginine, which the body uses to make nitric oxide, a molecule that widens blood vessels. This should improve blood flow and oxygen delivery to muscles during intense exercise, but in healthy adults, this does not result in more oxygen reaching the working muscles or longer exercise time.
What the research says
1 studyThis study gave young, healthy adults L-citrulline pills for 10 days and had them cycle until they were too tired to continue. They didn’t last any longer than when they took a sugar pill, so the supplement didn’t help them cycle longer.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.