The Claim
Acute ingestion of 6 g and 12 g citrulline malate produces a dose-dependent increase in serum concentrations of citrulline, arginine, and ornithine in healthy young males, with peak levels occurring at 30–60 minutes post-ingestion and significantly higher concentrations following the 12 g dose.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When healthy young men take 6 grams or 12 grams of citrulline malate, their blood levels of citrulline, arginine, and ornithine rise in proportion to the dose, with the highest levels reached 30 to 60 minutes after ingestion and higher levels seen with the 12-gram dose.
See the scientific wording
Acute ingestion of 6 g and 12 g citrulline malate produces a dose-dependent increase in serum concentrations of citrulline, arginine, and ornithine in healthy young males, with peak levels occurring at 30–60 minutes post-ingestion and significantly higher concentrations following the 12 g dose.
When citrulline malate is swallowed, it breaks down into citrulline, which enters the bloodstream. The kidneys take up citrulline and turn it into arginine and ornithine. More citrulline leads to more arginine and ornithine in the blood, and a higher dose produces even higher levels. These levels peak about half an hour to an hour after ingestion.
What the research says
1 studyWhen healthy young men took 6 grams or 12 grams of citrulline malate, their blood levels of citrulline, arginine, and ornithine went up — and the higher dose (12 grams) made them go up even more, within about an hour. The study directly measured this and confirmed it.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.