The Claim

An 8-week supplementation with 1500 mg/day of creatine hydrochloride increases frontal brain creatine levels by 16.4% compared to a 0.9% increase in the placebo group (p < 0.01) in perimenopausal and menopausal women, suggesting enhanced cerebral energy metabolism.

Source: The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
59score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Taking 1500 mg of creatine hydrochloride daily for 8 weeks increases creatine levels in the frontal brain by 16.4% in perimenopausal and menopausal women, while placebo only increased by 0.9%. This suggests the brain's energy metabolism is enhanced.

See the scientific wording

An 8-week supplementation with 1500 mg/day of creatine hydrochloride increases frontal brain creatine levels by 16.4% compared to a 0.9% increase in the placebo group (p < 0.01) in perimenopausal and menopausal women, suggesting enhanced cerebral energy metabolism.

Why this might work

Taking creatine hydrochloride daily for 8 weeks raises the amount of creatine in the brain. Creatine is stored in brain cells and helps them produce energy quickly by regenerating ATP, the energy currency of cells. With more creatine, brain cells can better maintain energy levels during mental tasks, leading to faster thinking and reaction times.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial.

    The study found that taking 1500 mg of creatine hydrochloride daily for 8 weeks raised brain creatine levels by 16.4% in menopausal women, which matches the claim exactly.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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