The Claim

The co-ingestion of 400 mg caffeine and 5 g creatine nitrate for seven days has no adverse effect on resting heart rate, blood pressure, creatine kinase, liver enzymes, or lipid profiles in resistance-trained male athletes.

Source: The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
74score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Description
1 study reviewed
In plain English

Taking 400 mg of caffeine and 5 g of creatine nitrate together for seven days does not change resting heart rate, blood pressure, or levels of liver, kidney, or metabolic markers in male athletes who train with weights.

See the scientific wording

The co-ingestion of 400 mg caffeine and 5 g creatine nitrate for seven days does not adversely affect cardiovascular hemodynamics or blood biomarkers of liver, kidney, or metabolic function in resistance-trained male athletes, as measured by resting heart rate, blood pressure, creatine kinase, liver enzymes, and lipid profiles.

Why this might work

The body absorbs caffeine and creatine nitrate, and while caffeine slightly increases brain activity by blocking a calming signal, creatine nitrate provides extra energy to brain cells and widens blood vessels slightly. These changes do not trigger stress responses in the heart, liver, kidneys, or metabolism because the body’s natural systems keep everything in balance, and no harmful changes occur in heart rate, blood pressure, or blood markers.

Supported mechanismbased on 1 study

What the research says

1 study

  1. Study: The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial

    This study gave 12 healthy male athletes 400 mg of caffeine and 5 g of creatine nitrate together for a week and checked their heart rate, blood pressure, and blood markers for liver, kidney, and cholesterol. Nothing bad happened — no side effects were reported, so it’s safe.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.