The Claim
Acute ingestion of 6 g and 12 g citrulline malate in healthy young males produces a dose-dependent increase in serum concentrations of citrulline, arginine, and ornithine, with peak levels occurring at 30–60 minutes post-ingestion, confirming its role as an effective precursor for arginine bioavailability.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When healthy young men take 6 grams or 12 grams of citrulline malate, their blood levels of citrulline, arginine, and ornithine rise in proportion to the dose, and these levels peak between 30 and 60 minutes after ingestion.
See the scientific wording
Acute ingestion of 6 g and 12 g citrulline malate in healthy young males produces a dose-dependent increase in serum concentrations of citrulline, arginine, and ornithine, with peak levels occurring at 30–60 minutes post-ingestion, confirming its role as an effective precursor for arginine bioavailability.
When citrulline malate is swallowed, it breaks down into citrulline, which enters the bloodstream. The kidneys take up this citrulline and turn it into arginine and ornithine, which then spill into the blood. More citrulline leads to more arginine and ornithine, and this happens fastest 30 to 60 minutes after taking it.
What the research says
1 studyTaking 6 or 12 grams of citrulline malate makes more citrulline and arginine show up in the blood, and the higher dose makes even more appear — just like the claim says. It doesn't say anything about whether this makes your muscles or arteries work better, but that's not what the claim is about.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.