Taking 83 micrograms of L-selenomethionine daily during pregnancy and for six months after childbirth is associated with lower levels of specific antibodies targeting the thyroid in women with autoimmune thyroiditis, compared to those taking a placebo.

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Pro

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Against

Evidence from Studies

Supporting (1)

67

Community contributions welcome

67

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial

Randomized Controlled Trial

Human

2019 Dec

This study found that taking a specific selenium supplement during and after pregnancy helped lower harmful antibodies in women with thyroid problems, while those who took a dummy pill saw their antibodies go up. So yes, the supplement seems to help calm the immune system’s attack on the thyroid after birth.

Contradicting (0)

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Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial

Score: 67

DOI: 10.1007/s12020-019-01958-1

Similar Assertions

In women with autoimmune thyroiditis, levels of thyroid autoantibodies typically drop during pregnancy and rise again after childbirth unless selenium is taken, which may help prevent this increase.

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88%

Taking 83 micrograms of L-selenomethionine daily during pregnancy does not change thyroid hormone levels, thyroid size, or tissue appearance in women with autoimmune thyroiditis. This suggests the supplement affects immune markers related to the thyroid without altering thyroid structure or function.

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85%

Taking selenium supplements during pregnancy does not improve or worsen the mother's well-being, pregnancy complications, or baby's health outcomes in women with autoimmune thyroiditis.

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76%

Taking selenium supplements may lower levels of thyroid peroxidase antibodies in adults with chronic autoimmune thyroiditis who are already taking levothyroxine, with the greatest reduction seen at six months. However, it does not change thyroid-stimulating hormone levels or improve symptoms related to the condition.

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70%

When pregnant women take a daily supplement of 83 micrograms of L-selenomethionine, their blood selenium levels rise significantly and remain higher than those of women taking a placebo, even six months after giving birth.

67

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70%